IMPROVING BACTERICIDAL PERFORMANCE OF IMPLANT COMPOSITE COATINGS BY SYNERGISM BETWEEN MELITTIN AND TETRACYCLINE

Improving bactericidal performance of implant composite coatings by synergism between Melittin and tetracycline

Abstract Methicillin resistance Staphylococcus aureus bacteria (MRSA) are serious hazards of bone implants.The present study was aimed to use the potential synergistic effects of Melittin and tetracycline to prevent MRSA associated bone implant infection.Chitosan/bioactive glass nanoparticles/tetracycline composite coatings were deposited on hydrot

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Comprehensive discovery of CRISPR-targeted terminally redundant sequences in the human gut metagenome: Viruses, plasmids, and more

Viruses are the most numerous biological entity, existing in all environments and infecting all cellular organisms.Compared with cellular life, the evolution and origin of viruses are poorly understood; viruses are enormously diverse, and most lack sequence similarity to cellular genes.To uncover viral sequences without relying on either reference

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An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

DNA methylation is extensively remodeled during mammalian gametogenesis and embryogenesis.Most transposons become hypomethylated, raising the question of their regulation in the absence of DNA methylation.To reproduce a rapid and extensive demethylation, we subjected mouse ES cells to chemically defined hypomethylating culture conditions.Surprising

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